Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
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چکیده
منابع مشابه
Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity.
PURPOSE To identify determinants of the effect of antisense-mediated Bcl-xl down-regulation (Bcl-xl knockdown) on the response of colorectal cancer cells to SN38, the active metabolite of irinotecan, a topoisomerase I inhibitor licensed for colorectal cancer chemotherapy. EXPERIMENTAL DESIGN Using wild-type HCT116, p53 null, Bax null, or p21/WAF1 null isogenic derivatives, we measured express...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2012
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-12-0207